Dextran Magnetite (DM)

Dextran magnetite (DM) is a generic name of hydrophilic colloidal solution of superparamagnetic iron oxide coated with various dextran derivative. DM can get various functionality by changing the structure of the coating material around magnetic iron oxide core.

Series	Composition	Purpose
ATDM	Alkali-treated Dextran Superparamagnetic iron oxide nano particles Water	Drug substance of MRI-contrast media Magnetic tracer MPI tracer Reagent
CMDM	Carboxymethyl Dextran Superparamagnetic iron oxide nano particles Water	Reagent
CMEADM	Carboxymethyl diethylaminoethyl Dextran Superparamagnetic iron oxide nano particles Water	Reagent
Cationic DM	Cationic Dextran Superparamagnetic iron oxide nano particles Water	Reagent

Applied Example [ MRI Contrast Media ] DM is safer than the gadolinium-based contrast media which are generally used. Now, DM is used for the drug substance of liver specific MRI-contrast media. Lawaczeck et al.,: Magnetic iron oxide particles coated with Carboxydextran for parenteral administration and liver contrasting. Acta Radiologica 38, 584, 1997 [ Tracer for sentinel lymph node biopsy ] DM is safe in a human body compared with the radio isotope tracer which is generally used. DM is used already in abroad. Douek et al.,: Sentinel node biopsy using a magnetic tracer vs. standard technique: The Sentimag Multicentre Trial. Ann Surg Oncol; Vol 21(4), 1237, 2014 [ Trasor for Magnetic Particle Imaging ] DM is used as a tracer indispensable to MPI where development is advanced as a new diagnostic imaging. The MPI is in the pre-clinical stage at present. Panagiotopoulos et al.,: Magnetic Particle Imaging: current developments and future directions. Int. J. NanoMed., 10, 3097, 2015 [ Hyperthermia ] The remedy which makes cancer perish by heat is conducted in abroad. The feature is that there are few side effects. DM where the dosage is possible is effective for the human body as a fever element. Kallimadil et al.,: Suitability of commercial colloids for magnetic hyperthermia. J. Magnetism and Magnetic Materials, 321, 1509, 2009 Kita et al., ;Heating characteristics of ferromagnetic iron oxide nanoparticles for magnetic hyperthermia. J. Applied Physics, 107, 09B321, 2010 [ Drug Delivery System ] At present, it is still a study stage. Because an instruction is possible from the outside the body by a magnet, it is expected as a DDS material .